GNE-9822
Product Specifications
UNSPSC Description
GNE-9822 is a potent, orally active and selective ITK inhibitor with a Ki value of 0.7 nM, and an EC50 value of 354.5 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma[1][2].
Target Antigen
Itk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gne-9822.html
Purity
95.0
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CN(C)CC[C@H](N1N=CC(NC(C2=NNC3=C2CCC(C)(C)C3)=O)=C1)C4=CC=CC=C4
Molecular Weight
420.55
References & Citations
[1]Burch JD, et, al. Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors. J Med Chem. 2014 Jul 10;57(13):5714-27.|[2]Zhou D, et al. Discovery of Potent and Highly Selective Interleukin-2-Inducible T-Cell Kinase Degraders with In Vivo Activity. J Med Chem. 2023 Apr 13;66(7):4979-4998.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12410/GNE-9822-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12410/GNE-9822-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1557232-32-2
Available Sizes
Curated Selection
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