(Rac) -LM11A-31 (dihydrochloride)
(Rac) -LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist[1].
Product Specifications
CAS Number
1214672-15-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H410
Target
Drug Isomer
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rac-lm11a-31-dihydrochloride.html
Purity
99.41
Solubility
Ethanol : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCC(C)C(N)C(NCCN1CCOCC1)=O.[H]Cl.[H]Cl
Molecular Formula
C12H27Cl2N3O2
Molecular Weight
316.27
Precautions
H315, H319, H335, H410
References & Citations
[1]Elshaer SL, et al. Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinalvascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. 2019 Aug;62 (8) :1488-1500.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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