(Rac) -LM11A-31 (dihydrochloride)

(Rac) -LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist[1].

Product Specifications

CAS Number

[1214672-15-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H410

Target

Drug Isomer

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rac-lm11a-31-dihydrochloride.html

Purity

99.41

Solubility

Ethanol : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCC(C)C(N)C(NCCN1CCOCC1)=O.[H]Cl.[H]Cl

Molecular Formula

C12H27Cl2N3O2

Molecular Weight

316.27

Precautions

H315, H319, H335, H410

References & Citations

[1]Elshaer SL, et al. Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinalvascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. 2019 Aug;62 (8) :1488-1500.