CGP-42112

CGP-42112 (CGP-42112A) is a potent Angiotensin-II subtype 2 receptor (AT2 R) agonist[1].

Product Specifications

CAS Number

[127060-75-7]

Product Name Alternative

CGP42112A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/CGP-42112.html

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC[C@H](C)[C@@H](C(O)=O)NC([C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H](CCCCNC([C@H](CCCNC(N)=N)NC(OCC3=CC=CC=C3)=O)=O)NC([C@H](CC4=CC=C(C=C4)O)NC(C5=CC=CN=C5)=O)=O)=O)=O)CCC1)=O

Molecular Formula

C52H69N13O11

Molecular Weight

1052.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Takekoshi K, et al. Angiotensin-II subtype 2 receptor agonist (CGP-42112) inhibits catecholamine biosynthesis in cultured porcine adrenal medullary chromaffin cells. Biochem Biophys Res Commun. 2000 Jun 7;272 (2) :544-50.|[2]Speth RC. [125I]CGP 42112 binding reveals differences between rat brain and adrenal AT2 receptor binding sites. Regul Pept. 1993 Mar 19;44 (2) :189-97.|[3]Naveri L, et al. Angiotensin II AT2 receptor stimulation extends the upper limit of cerebral blood flow autoregulation: agonist effects of CGP 42112 and PD 123319. J Cereb Blood Flow Metab. 1994 Jan;14 (1) :38-44.|[4]Heemskerk FM, et al. Quantitative autoradiography of angiotensin II AT2 receptors with [125I]CGP 42112. Brain Res. 1995 Apr 17;677 (1) :29-38.