N-Oxalylglycine
N-Oxalylglycine (N-Oxaloglycine) is a Jumonji C-domain-containing histone lysine demethylase inhibitor. N-Oxalylglycine inhibits JMJD2A, JMJD2C and JMJD2D. N-Oxalylglycine also inhibits HIF prolylhydroxylase domain-1 (PHD-1) and PHD-2, with an IC50 of 2.1 μM and 5.6 μM, respectively[1][2].
Product Specifications
CAS Number
5262-39-5
Product Name Alternative
N-Oxaloglycine
UNSPSC
12352211
Hazard Statement
H302, H372, H411
Target
HIF/HIF Prolyl-Hydroxylase; Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-oxalylglycine.html
Purity
99.28
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CNC(C(O)=O)=O
Molecular Formula
C4H5NO5
Molecular Weight
147.09
Precautions
H302, H372, H411
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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