N-Oxalylglycine

N-Oxalylglycine (N-Oxaloglycine) is a Jumonji C-domain-containing histone lysine demethylase inhibitor. N-Oxalylglycine inhibits JMJD2A, JMJD2C and JMJD2D. N-Oxalylglycine also inhibits HIF prolylhydroxylase domain-1 (PHD-1) and PHD-2, with an IC50 of 2.1 μM and 5.6 μM, respectively[1][2].

Product Specifications

CAS Number

[5262-39-5]

Product Name Alternative

N-Oxaloglycine

UNSPSC

12352211

Hazard Statement

H302, H372, H411

Target

HIF/HIF Prolyl-Hydroxylase; Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-oxalylglycine.html

Purity

99.28

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CNC(C(O)=O)=O

Molecular Formula

C4H5NO5

Molecular Weight

147.09

Precautions

H302, H372, H411

References & Citations

[1]Hamada S, et al. Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors. Bioorg Med Chem Lett. 2009 May 15;19 (10) :2852-5. |[2]Hamada S, et al. Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors. J Med Chem. 2010 Aug 12;53 (15) :5629-38.