HPK1-IN-52

HPK1-IN-52 is a potent and orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 10.4 nM. HPK1-IN-52 exhibits anti-tumor activities[1].

Product Specifications

CAS Number

[2994298-66-5]

UNSPSC

12352005

Target

MAP4K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hpk1-in-52.html

Smiles

O=C1NC=CC2=C1C(NC3=NC(CN4C[C@@H](F)CC4)=C(C5CCOCC5)C=C3)=CC=C2C6=CN=C7C=C(F)C=CN76

Molecular Formula

C31H30F2N6O2

Molecular Weight

556.61

References & Citations

[1]Jingjing Peng, et al. Discovery of 1 (2H) -phthalazinone and 1 (2H) -isoquinolinone derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors. European Journal of Medicinal Chemistry. Volume 279, 5 December 2024, 116877.