HPK1-IN-52
Product Specifications
UNSPSC Description
HPK1-IN-52 is a potent and orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 10.4 nM. HPK1-IN-52 exhibits anti-tumor activities[1].
Target Antigen
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-52.html
Smiles
O=C1NC=CC2=C1C(NC3=NC(CN4C[C@@H](F)CC4)=C(C5CCOCC5)C=C3)=CC=C2C6=CN=C7C=C(F)C=CN76
Molecular Weight
556.61
References & Citations
[1]Jingjing Peng, et al. Discovery of 1(2H)-phthalazinone and 1(2H)-isoquinolinone derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors. European Journal of Medicinal Chemistry. Volume 279, 5 December 2024, 116877.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168110/HPK1-IN-52-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168110/
Clinical Information
No Development Reported
CAS Number
2994298-66-5
Curated Selection
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