Decapeptide-12

Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM) . Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM) . Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation [1][2][3].

Product Specifications

CAS Number

[137665-91-9]

UNSPSC

12352209

Target

Sirtuin; Tyrosinase

Type

Peptides

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/decapeptide-12.html

Purity

99.95

Solubility

H2O : ≥ 100 mg/mL

Smiles

[Y][R]S[R]([Y]=S=S=[W][Y])[K]

Molecular Formula

C65H90N18O17

Molecular Weight

1395.52

References & Citations

[1]Anan Abu Ubeid, et al. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J Invest Dermatol. 2009 Sep;129 (9) :2242-9. |[2]Akihito Ochiai, et al. New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues. J Biosci Bioeng. 2016 Jun;121 (6) :607-613. |[3]Basil M H, et al. Tyrosinase inhibitors with potent anti-senescence activity in human neonatal keratinocyte progenitors. J Dermatol Surg Res Ther, 2019, 2019: 30-39.