SphK1&2-IN-1

SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2].

Product Specifications

CAS Number

[1415662-57-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

SphK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sphk1-2-in-1.html

Purity

99.33

Solubility

DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=C(C=CC(/C=C/C(NC2=NC=CS2)=O)=C1)OC

Molecular Formula

C14H14N2O3S

Molecular Weight

290.34

Precautions

H302, H315, H319

References & Citations

[1]Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22 (19) :5354-67. |[2]Nong W, et al. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27 (18) :4506-4511.