GSK-3β inhibitor 3
Product Specifications
UNSPSC Description
GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia[1].
Target Antigen
Apoptosis; GSK-3
Type
Reference compound
Related Pathways
Apoptosis;PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk-3β-inhibitor-3.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C=C1)=CC=C1C2CC(N(C(C=C)=O)C3=CC=CC=C3S2)=O
Molecular Weight
327.37
References & Citations
[1]Zhang P, et, al. Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia. J Med Chem. 2021 May 24.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141480/GSK-3β-inhibitor-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141480/GSK-3β-inhibitor-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1448990-73-5
Available Sizes
Curated Selection
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