GSK-3β inhibitor 3

GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia[1].

Product Specifications

CAS Number

[1448990-73-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; GSK-3

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gsk-3β-inhibitor-3.html

Purity

99.22

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(C=C1)=CC=C1C2CC(N(C(C=C)=O)C3=CC=CC=C3S2)=O

Molecular Formula

C18H14FNO2S

Molecular Weight

327.37

Precautions

H302, H315, H319

References & Citations

[1]Zhang P, et, al. Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia. J Med Chem. 2021 May 24.