NLS (PKKKRKV)

NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].

Product Specifications

CAS Number

[95088-49-6]

UNSPSC

12352209

Hazard Statement

H302, H315, H319

Target

DNA/RNA Synthesis

Type

Peptides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nls-pkkkrkv.html

Purity

99.03

Solubility

10 mM in DMSO

Smiles

CC(C)[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H]1NCCC1)=O)=O)=O)=O)=O)=O

Molecular Formula

C40H78N14O8

Molecular Weight

883.14

Precautions

H302, H315, H319

References & Citations

[1]Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96 (1) :91-6.|[2]Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound‑targeted microbubble destruction‑mediated gene transfection. Mol Med Rep. 2017 Jul;16 (1) :565-572.