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Dabcyl-QALPETGEE-Edans

Dabcyl-QALPETGEE-Edans is a synthetic peptide substrate for fluorescence resonance energy transfer (FRET) detection of Sortase A (SrtA) enzymatic activity. Dabcyl-QALPETGEE-Edans is labeled at both ends with the fluorescent group Edans (donor) and the quencher Dabcyl (acceptor), respectively. Dabcyl-QALPETGEE-Edans's central sequence contains a conserved motif specifically recognized by SrtA. Dabcyl-QALPETGEE-Edans demonstrates high sensitivity in vitro assays, enabling precise determination of the half-maximal inhibitory concentration of SrtA[1].

Product Specifications

CAS Number

[271798-75-5]

UNSPSC

12352209

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dabcyl-qalpetgee-edans.html

Purity

98.00

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(/N=N/C2=CC=C(N(C)C)C=C2)C=C1)N[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCCNC4=CC=CC5=C4C=CC=C5S(=O)(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)CCC(O)=O)=O)CCC3)=O)CC(C)C)=O)C)=O)CCC(N)=O

Molecular Formula

C67H89N15O21S

Molecular Weight

1472.58

References & Citations

[1]Hu P, et al. Curcumin reduces Streptococcus mutans biofilm formation by inhibiting sortase A activity. Arch Oral Biol. 2013 Oct;58 (10) :1343-8.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

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