Licostinel
Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM) . Licostinel has neuroprotective activity[1][2][3].
Product Specifications
CAS Number
153504-81-5
Product Name Alternative
ACEA-1021
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/licostinel.html
Purity
98.12
Solubility
10 mM in DMSO|DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC2=C(NC1=O)C([N+]([O-])=O)=C(C(Cl)=C2)Cl
Molecular Formula
C8H3Cl2N3O4
Molecular Weight
276.04
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhou ZL, et al. Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists. Bioorg Med Chem. 2003 Apr 17;11 (8) :1769-80.|[2]Albers GW, et al. Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke. Stroke. 1999 Mar;30 (3) :508-13.|[3]Martin H, et al. Effects of glycine receptor antagonism on spreading depression in the rat. Neurosci Lett. 1994 Oct 24;180 (2) :285-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
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