MK-8141
MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA) . This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition.
Product Specifications
CAS Number
903579-36-2
Product Name Alternative
ACT-077825
UNSPSC
12352005
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mk-8141.html
Smiles
O=C(C1=C(C2=CC=C(OCCOC3=C(Cl)C=C(C)C=C3Cl)C=C2)C[C@]4([H])CNC[C@@]1([H])N4)N(C5CC5)CC6=CC=CC(C)=C6C
Molecular Formula
C35H39Cl2N3O3
Molecular Weight
620.61
References & Citations
[1]Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors
 J. Med. Chem., 2009, 52 (12), pp 3689-3702
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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