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Anti-inflammatory agent 49

Nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC50 of SC9 inhibiting GTPase in vitro is 270 nM[1].

Product Specifications

CAS Number

[851471-44-8]

UNSPSC

12352005

Target

Dynamin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-49.html

Purity

98.26

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC(N(CC2=CC=CC=C2)C(N)=C1N(C)C(CSC3=NN4C(C)=CC(C)=NC4=N3)=O)=O

Molecular Formula

C21H22N8O3S

Molecular Weight

466.52

References & Citations

[1]Luis Rios, et al. Targeting an allosteric site in dynaminrelated protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nat Commun. 2023 Jul 19;14 (1) :4356

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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