ST4206
ST4206 is a potent and orally active adenosine A2A receptor antagonist, with Kis of 12 nM and 197 nM for adenosine A2A receptor and adenosine A1 receptor, respectively. ST4206 has the potential for Parkinson s disease research[1].
Product Specifications
CAS Number
1246018-36-9
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-Butanone,_4-[6-amino-9-methyl-8-_2H-1,2,3-triazol-2-yl_-9H-purin-2-yl]-.html
Solubility
10 mM in DMSO
Smiles
CC(CCC1=NC(N)=C2N=C(N3N=CC=N3)N(C)C2=N1)=O
Molecular Formula
C12H14N8O
Molecular Weight
286.29
References & Citations
[1]Maria Antonietta Stasi, et al. Animal models of Parkinson׳s disease: Effects of two adenosine A2A receptor antagonists ST4206 and ST3932, metabolites of 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535) . Eur J Pharmacol. 2015 Aug 15;761:353-61.|[2]de Lera Ruiz M, et al. Adenosine A2A receptor as a drug discovery target. J Med Chem. 2014 May 8;57 (9) :3623-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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