EBOV/MARV-IN-1

EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC50=0.31, and 0.82 μM, respectively) and low cytotoxicity (SI>100) in HeLa cells[1].

Product Specifications

CAS Number

[2479465-67-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Filovirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ebov-marv-in-1.html

Purity

99.14

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(N2CCC(C)CC2)C(C(F)(F)F)=C1)C3=CC=C(CN4CCOCC4)C=C3

Molecular Formula

C25H30F3N3O2

Molecular Weight

461.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Gaisina IN, et, al. Discovery and Structural Optimization of 4- (Aminomethyl) benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. J Med Chem. 2020 Jul 9;63 (13) :7211-7225.