β-Carotene (Standard)

β-Carotene (Standard) is the analytical standard of β-Carotene. This product is intended for research and analytical applications. β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities[1][2][3][4][5].

Product Specifications

CAS Number

[7235-40-7]

Product Name Alternative

Provitamin A (Standard) ; beta-Carotene (Standard)

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Apoptosis; Endogenous Metabolite; Reactive Oxygen Species (ROS) ; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/β-carotene-standard.html

Purity

97.28

Smiles

CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)=C(C)CCC1

Molecular Formula

C40H56

Molecular Weight

536.87

Precautions

H315, H319, H335

References & Citations

[1]Tanumihardjo, S.A., Factors influencing the conversion of carotenoids to retinol: bioavailability to bioconversion to bioefficacy. Int J Vitam Nutr Res, 2002. 72 (1) : p. 40-5.|[2]Leo, M.A., et al. Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity. Am J Clin Nutr, 1999. 69 (6) : p. 1071-85.|[3]Yanhong Cui, et al. beta-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells. Eur J Cancer. 2007 Nov;43 (17) :2590-601.|[4]Paola Palozza, et al. Prooxidant effects of beta-carotene in cultured cells. Mol Aspects Med. 2003 Dec;24 (6) :353-62.|[5]AKIFUMI KAWATA, et al. Anti-inflammatory Activity of β-Carotene, Lycopene and Tri-n-butylborane, a Scavenger of Reactive Oxygen Species. In Vivo. 2018 Mar-Apr; 32 (2) : 255-264.