Spautin-1
Spautin-1 is a specific and potent autophagy inhibitor which inhibits ubiquitin-specific peptidases, USP10 and USP13 with IC50s of 0.6-0.7 μM.
Product Specifications
CAS Number
1262888-28-7
UNSPSC
12352005
Hazard Statement
H302, H318
Target
Apoptosis; Autophagy; Deubiquitinase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Spautin-1.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC2=C(N=CN=C2C=C1)NCC3=CC=C(F)C=C3
Molecular Formula
C15H11F2N3
Molecular Weight
271.26
Precautions
H302, H318
References & Citations
[1]Shao S, et al. Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia. Int J Oncol. 2014 May;44 (5) :1661-1668.|[2]Xiao J, et al. Spautin-1 Ameliorates Acute Pancreatitis via Inhibiting Impaired Autophagy and Alleviating Calcium Overload. Mol Med. 2016 Aug 18;22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
USP10
Available Sizes
Frequently Asked Questions
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