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Spautin-1

Spautin-1 is a specific and potent autophagy inhibitor which inhibits ubiquitin-specific peptidases, USP10 and USP13 with IC50s of 0.6-0.7 μM.

Product Specifications

CAS Number

1262888-28-7

UNSPSC

12352005

Hazard Statement

H302, H318

Target

Apoptosis; Autophagy; Deubiquitinase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Spautin-1.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC1=CC2=C(N=CN=C2C=C1)NCC3=CC=C(F)C=C3

Molecular Formula

C15H11F2N3

Molecular Weight

271.26

Precautions

H302, H318

References & Citations

[1]Shao S, et al. Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia. Int J Oncol. 2014 May;44 (5) :1661-1668.|[2]Xiao J, et al. Spautin-1 Ameliorates Acute Pancreatitis via Inhibiting Impaired Autophagy and Alleviating Calcium Overload. Mol Med. 2016 Aug 18;22.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

USP10

Available Sizes

Frequently Asked Questions

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