5-Hydroxymethyl-2’-deoxycytidine

5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2’-deoxycytidine may serve as a marker of irreversibly damaged cells[1][2].

Product Specifications

CAS Number

[7226-77-9]

Product Name Alternative

5hmdC

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

DNA/RNA Synthesis; Drug Derivative

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/5-hydroxymethyl-2-deoxycytidine.html

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O[C@H]1C[C@H](N2C(N=C(N)C(CO)=C2)=O)O[C@@H]1CO

Molecular Formula

C10H15N3O5

Molecular Weight

257.24

Precautions

H302, H315, H319

References & Citations

[1]Ewelina Zarakowska, et al. Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73 (8) :1003-1009.|[2]Shuo Liu, et al. Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res. 2013 Jul;41 (13) :6421-9.|[3]Tang Y, et al., Sensitive and simultaneous determination of 5-methylcytosine and its oxidation products in genomic DNA by chemical derivatization coupled with liquid chromatography-tandem mass spectrometry analysis. Anal Chem. 2015 Mar 17;87 (6) :3445-52.|[4]Zhang HY, et al., The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals. Chem Commun (Camb) . 2016 Jan 14;52 (4) :737-40.