Glabrescione B
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells[1][2].
Product Specifications
CAS Number
[65893-94-9]
UNSPSC
12352005
Target
Gli
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/glabrescione-b.html
Purity
98.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(C2=CC=C(OC/C=C(C)/C)C(OC/C=C(C)/C)=C2)=COC3=CC(OC)=CC(OC)=C13
Molecular Formula
C27H30O6
Molecular Weight
450.52
References & Citations
[1]Ingallina C, et al. Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro. Nanomedicine (Lond) . 2017;12 (7) :711-728.|[2]Infante P, et al. Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors. EMBO J. 2015;34 (2) :200-217.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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