Metoprine

Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT[1][2]. Metoprine is an antifolate and antitumor agent[3].

Product Specifications

CAS Number

[7761-45-7]

Product Name Alternative

BW 197U

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Antifolate; Histone Methyltransferase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/metoprine.html

Purity

99.67

Solubility

DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=C(C(N)=NC(N)=N1)C2=CC=C(C(Cl)=C2)Cl

Molecular Formula

C11H10Cl2N4

Molecular Weight

269.13

Precautions

H315, H319, H320

References & Citations

[1]Junichi Kitanaka, et al. Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose. Drug Target Insights. 2016 Mar 2;10:1-7.|[2]Zhong Chen, et al. Effects of brain histamine on memory deficit induced by nucleus basalis-lesion in rats. Acta Pharmacol Sin. 2002 Jan;23 (1) :66-70.|[3]John R Horton, et al. Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. J Mol Biol. 2005 Oct 21;353 (2) :334-344.