SphK2-IN-3
SphK2-IN-3 (compound 12q) is a selective active sphingosine kinase-2 inhibitor. SphK2-IN-3 has anti-proliferative activity against various cancer cells, inducing G2 phase arrest and apoptosis in liver cancer cells HepG2[1].
Product Specifications
UNSPSC
12352005
Target
SphK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sphk2-in-3.html
Smiles
ClC1=C(Cl)C=CC(COC2=CC=C(C3=CC=C(CC(N4CCC[C@H]4CO)=O)C=C3)C=N2)=C1
Molecular Formula
C25H24Cl2N2O3
Molecular Weight
471.38
References & Citations
[1]Yanan Li, et al. Discovery and biological evaluation of biaryl acetamide derivatives as selective and in vivo active sphingosine kinase-2 inhibitors. Eur J Med Chem. 2024 Jun 8:275:116577.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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