SphK2-IN-3

SphK2-IN-3 (compound 12q) is a selective active sphingosine kinase-2 inhibitor. SphK2-IN-3 has anti-proliferative activity against various cancer cells, inducing G2 phase arrest and apoptosis in liver cancer cells HepG2[1].

Product Specifications

UNSPSC

12352005

Target

SphK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sphk2-in-3.html

Smiles

ClC1=C(Cl)C=CC(COC2=CC=C(C3=CC=C(CC(N4CCC[C@H]4CO)=O)C=C3)C=N2)=C1

Molecular Formula

C25H24Cl2N2O3

Molecular Weight

471.38

References & Citations

[1]Yanan Li, et al. Discovery and biological evaluation of biaryl acetamide derivatives as selective and in vivo active sphingosine kinase-2 inhibitors. Eur J Med Chem. 2024 Jun 8:275:116577.