P2X7 receptor antagonist-2
P2X7 receptor antagonist-2 is a potent P2X7 receptor antagonist with a pIC50 value of 6.5-7.5. P2X7 receptor antagonist-2 has efficacy of combating neuroinflammation[1].
Product Specifications
CAS Number
[851269-75-5]
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/p2x7-receptor-antagonist-2.html
Purity
99.21
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC(Cl)=C(CNC(C2CN(C(C2)=O)CC3=CC=CC=C3)=O)C=C1
Molecular Formula
C19H18Cl2N2O2
Molecular Weight
377.26
References & Citations
[1]Steadman JGA, et, al. 5-oxo-3-pyrrolidinecarboxamide derivatives as p2x7 modulators. WO2009077559A2
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X7 Receptor
Available Sizes
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