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Tegafur-Uracil

Tegafur-Uracil (UFT; BMS-200604) is an effective oral chemotherapy drug based on fluoropyrimidine. Tegafur-Uracil inhibits thymidylate synthase. Tegafur-Uracil can be used in combination with leucovorin (LV) and polysaccharide K (PSK) for research on solid tumors[1][2].

Product Specifications

CAS Number

74578-38-4

Product Name Alternative

UFT; BMS-200604

UNSPSC

12352005

Target

Thymidylate Synthase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tegafur-uracil.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=CNC(N1)=O.O=C2NC(N(C3OCCC3)C=C2F)=O

Molecular Formula

C12H13FN4O5

Molecular Weight

312.25

References & Citations

[1]Casado E, et al. UFT (tegafur-uracil) in rectal cancer. Ann Oncol. 2008;19 (8) :1371-1378.|[2]Ryoji Katoh, et al. Enhancement of antitumor effect of tegafur/uracil (UFT) plus leucovorin by combined treatment with protein-bound polysaccharide, PSK, in mouse models. Cell Mol Immunol. 2007 Aug;4 (4) :295-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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