CZC-8004

CZC-8004 (CZC-00008004) is a pan-kinase inhibitor. CZC-8004 has IC50 values of 650 and 437 nM for EGFR WT and VEGFR2 V916M, respectively. CZC-8004 can be used in the study of cancer[1][2].

Product Specifications

CAS Number

[916603-07-1]

Product Name Alternative

CZC-00008004

UNSPSC

12352005

Hazard Statement

H302

Target

EGFR; VEGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CZC-8004.html

Concentration

10mM

Purity

99.81

Solubility

DMSO : 77.5 mg/mL (ultrasonic)

Smiles

FC1=CN=C(NC2=CC=C(CN)C=C2)N=C1NC3=CC=CC=C3

Molecular Formula

C17H16FN5

Molecular Weight

309.34

Precautions

H302

References & Citations

[1]Ying ZD, et, al. Integrated in silico-in vitro analysis of systematic kinase gatekeeper mutation effects on pan-kinase inhibitors in targeted liver cancer therapy. J Chin Chem Soc. 2020 Oct 29;1-10.|[2]Deane FM, et, al. FD5180, a Novel Protein Kinase Affinity Probe, and the Effect of Bead Loading on Protein Kinase Identification. ACS Omega. 2017 Jul 31;2 (7) :3828-3838.