JHU395
JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST[1].
Product Specifications
CAS Number
2079938-92-2
UNSPSC
12352005
Target
Drug Derivative
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jhu395.html
Purity
99.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(C)(C)C)OC(OC(N[C@@H](CCC(C=[N+]=[N-])=O)C(OC(C)C)=O)=O)C1=CC=CC=C1
Molecular Formula
C22H29N3O7
Molecular Weight
447.48
References & Citations
[1]Lemberg KM, et al. The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheralnerve sheath tumor. Mol Cancer Ther. 2019 Oct 8. pii: molcanther.0319.2019.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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