L 012 (sodium salt)

L 012 sodium salt is a luminal-based chemiluminescent probe. L 012 sodium salt can detect NADPH oxidase (Nox) -derived superoxide and nitrogen species (reactive oxygen species (ROS) and reactive nitrogen species (RNS) ) [1][2].

Product Specifications

CAS Number

[143556-24-5]

UNSPSC

12171500

Hazard Statement

H315, H319

Target

Reactive Oxygen Species (ROS)

Type

Dye Reagents

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/l-012-sodium-salt.html

Purity

99.63

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(C(Cl)=NC(C3=CC=CC=C3)=C2N)C(O[Na])=NN1

Molecular Formula

C13H8ClN4NaO2

Molecular Weight

310.67

Precautions

H315, H319

References & Citations

[1]Zielonka J, et al. On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. Free Radic Biol Med. 2013;65:1310-1314.|[2]Kielland A, et al. In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012. Free Radic Biol Med. 2009;47 (6) :760-766.