PTP1B-IN-20
PTP1B-IN-20 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50=78.0 μM), which is a key target for type 2 diabetes inhibition[1].
Product Specifications
CAS Number
3001295-81-1
UNSPSC
12352005
Target
Phosphatase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ptp1b-in-20.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C2=C(C(C3=C(C2=O)C=C(C(C)=C3O)O[C@H]4[C@H](O)[C@H]([C@@H]([C@H](O4)CO[C@@H]5OC[C@@H](O)[C@H](O)[C@H]5O)O)O)=O)C=C1)O
Molecular Formula
C26H28O15
Molecular Weight
580.49
References & Citations
[1]Zhang Z, et al. Selective Inhibition of PTP1B by New Anthraquinone Glycosides from Knoxia valerianoides. J Nat Prod. 2022 Nov 18.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
SGT1 (ECD) (NM_001135752) Human Over-expression Lysate
