Cytisinicline

Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. Has been used medically to help with smoking cessation[3].

Product Specifications

CAS Number

[485-35-8]

Product Name Alternative

Cytisine; Sophorine; Baptitoxine

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

NAChR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Cytisine.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C1N(C[C@@]2([H])C[C@]3([H])CNC2)C3=CC=C1

Molecular Formula

C11H14N2O

Molecular Weight

190.25

Precautions

H301, H315, H319, H335

References & Citations

[1]Pabreza LA, et al. [3H]cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol. 1991 Jan;39 (1) :9-12.|[2]Grebenstein PE, et al. The effects of noncontingent and self-administered cytisine on body weight and meal patterns in male Sprague-Dawley rats. Pharmacol Biochem Behav. 2013 Sep;110:192-200.|[3]Walker N, et al. Cytisine versus nicotine for smoking cessation. N Engl J Med. 2014 Dec 18;371 (25) :2353-62.|[4]Yu L, et al. Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells. Oncol Rep. 2018 Mar;39 (3) :1475-1484.