SDH-IN-1

SDH-IN-1 (compound 4i) is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 4.53 μM. SDH-IN-1 has potent antifungal activities. SDH-IN-1 displays potent activity against S. sclerotiorum (EC50 of 0.14 mg/L) [1].

Product Specifications

CAS Number

[2685795-52-0]

UNSPSC

12352005

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sdh-in-1.html

Purity

99.95

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(C1=NN=C(C2=CC=CS2)O1)NCC3=CC=C(Cl)C(Cl)=C3

Molecular Formula

C14H9Cl2N3O2S

Molecular Weight

354.21

References & Citations

[1]Zihui Yang, et al. Design, Synthesis, and Antifungal Activity of Novel Thiophene/Furan-1,3,4-Oxadiazole Carboxamides as Potent Succinate Dehydrogenase Inhibitors. J Agric Food Chem. 2021 Nov 17;69 (45) :13373-13385.