Kenpaullone
Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro.
Product Specifications
CAS Number
142273-20-9
Product Name Alternative
9-Bromopaullone; NSC-664704
UNSPSC
12352005
Hazard Statement
H315, H319
Target
CDK; GSK-3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Kenpaullone.html
Purity
98.20
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC=CC=C2C(NC3=C4C=C(Br)C=C3)=C4C1
Molecular Formula
C16H11BrN2O
Molecular Weight
327.18
Precautions
H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK5; GSK-3β
Available Sizes
Frequently Asked Questions
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