OB-24

OB-24 is a selective small-molecule HO-1 inhibitor (IC50 = 1.9 μM for HO-1 and IC50 for HO-2 >100 μM) . OB-24 possesses anti-tumor and anti-metastatic properties. OB-24 can be studies in research such as prostate cancer, melanoma, ovarian carcinoma and lung metastasis[1][2].

Product Specifications

CAS Number

[939825-12-4]

Product Name Alternative

BHI1

UNSPSC

12352005

Target

Heme Oxygenase (HO) ; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ob-24.html

Purity

98.21

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

BrC1=CC=C(CCC2(CN3C=CN=C3)OCCO2)C=C1.Cl

Molecular Formula

C15H18BrClN2O2

Molecular Weight

373.67

References & Citations

[1]Alaoui-Jamali MA, et al. A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 2009;69 (20) :8017-8024.|[2]Moulay. Alaoui-Jamali, et al., OB-24, a novel selective and potent HO-1 inhibitor, induces a wide spectrum anti-tumor activity in vitro and in vivo and synergizes with chemotherapy drugs. Mol Cancer Ther 1 November 2007; 6 (11_Supplement) : C82.|[3]Roman, G., et al., (2007) . Heme oxygenase inhibition by 2-oxy-substituted 1- (1H-imidazol-1-yl) -4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorganic & medicinal chemistry, 15 (9), 3225–3234.