HZ-1157

HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2].

Product Specifications

CAS Number

[1009734-33-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dengue Virus; Flavivirus; HCV Protease

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hz-1157.html

Concentration

10mM

Purity

98.16

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

NC1=NC(N)=C2C(OC(C)(C)C)=CC=CC2=N1

Molecular Formula

C12H16N4O

Molecular Weight

232.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Ye Yu, et al. Discovering Novel anti-HCV Compounds With Inhibitory Activities Toward HCV NS3/4A Protease. Acta Pharmacol Sin. 2014 Aug;35 (8) :1074-81.|[2]Bo Chao, et al. Discovery and Optimization of 2,4-diaminoquinazoline Derivatives as a New Class of Potent Dengue Virus Inhibitors. J Med Chem . 2012 Apr 12;55 (7) :3135-43.