PZ-II-029
PZ-II-029 is a GABAA positive allosteric modulator that selectively binds with high affinity to α6β3γ2. PZ-II-029 shows anti-migraine effects[1].
Product Specifications
CAS Number
164025-44-9
UNSPSC
12352005
Hazard Statement
H302
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pz-ii-029.html
Purity
99.23
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=C(OC)C=C2)N=C3C1=CNC4=C3C=CC(OC)=C4
Molecular Formula
C18H15N3O3
Molecular Weight
321.33
Precautions
H302
References & Citations
[1]Pi-Chuan Fan, et al. The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. 2018 Sep 15:140:1-13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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