Ro 20-1724
Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect[1][2].
Product Specifications
CAS Number
29925-17-5
Product Name Alternative
Ro 20-174
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro-20-1724.html
Purity
99.98
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1NC(CC2=CC=C(OC)C(OCCCC)=C2)CN1
Molecular Formula
C15H22N2O3
Molecular Weight
278.35
Precautions
H315, H319, H335
References & Citations
[1]Brackeen MF, et al. Design and synthesis of conformationally constrained analogues of 4- (3-butoxy-4-methoxybenzyl) imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase. J Med Chem. 1995;38 (24) :4848-4854. |[2]Sharma V, et al. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012;101 (2) :239-245.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4
Available Sizes
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