1-Hydroxy-2-naphthoic acid

1-Hydroxy-2-naphthoic acid is a polycyclic aromatic hydrocarbon (PAHs) degradation intermediate, mainly formed during the microbial degradation of aromatic hydrocarbons such as phenanthrene and naphthalene. 1-Hydroxy-2-naphthoic acid can undergo further hydroxylation, resulting in the naphthalene degradation pathway, or direct ring opening, leading to the phthalic acid pathway. 1-Hydroxy-2-naphthoic acid can be eliminated by introducing a heterologous salicylate hydroxylase gene (nahG) into the degrading bacterium[1][2].

Product Specifications

CAS Number

[86-48-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-hydroxy-2-naphthoic-acid.html

Purity

99.83

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=C2C=CC=CC2=C1O

Molecular Formula

C11H8O3

Molecular Weight

188.18

Precautions

H315, H319, H335

References & Citations

[1]Karale MA, et al. A Plasmid Induces Biodegradation of Pyrene by Bacillus cereus C7 and Identification of Its Degradation Metabolites. Indian J Microbiol. 2025 Jun;65 (2) :1047-1057.|[2]Ma J, et al. Study and Modification of the Polycyclic Aromatic Hydrocarbon Degradation Gene Cluster in Burkholderia sp. FM-2. Microorganisms. 2025 Sep 6;13 (9) :2079. PMID: 41011412; PMCID: PMC12472010.