PBD-150
PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM[1][2].
Product Specifications
CAS Number
790663-33-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pbd-150.html
Purity
99.53
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
S=C(NCCCN1C=CN=C1)NC2=CC=C(OC)C(OC)=C2
Molecular Formula
C15H20N4O2S
Molecular Weight
320.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Buchholz M, et al. The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem. 2006 Jan 26;49 (2) :664-77.|[2]DiPisa F, et al. The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease. Acta Crystallogr F Struct Biol Commun. 2015 Aug;71 (Pt 8) :986-92.|[3]Huang KF, et al. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. J Biol Chem. 2011 Apr 8;286 (14) :12439-49.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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