PBD-150

PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM[1][2].

Product Specifications

CAS Number

[790663-33-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pbd-150.html

Purity

99.53

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

S=C(NCCCN1C=CN=C1)NC2=CC=C(OC)C(OC)=C2

Molecular Formula

C15H20N4O2S

Molecular Weight

320.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Buchholz M, et al. The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem. 2006 Jan 26;49 (2) :664-77.|[2]DiPisa F, et al. The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease. Acta Crystallogr F Struct Biol Commun. 2015 Aug;71 (Pt 8) :986-92.|[3]Huang KF, et al. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. J Biol Chem. 2011 Apr 8;286 (14) :12439-49.