LLW-018
Product Specifications
UNSPSC Description
LLW-018 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 2.61 nM. LLW-018 can interrupt PD-1/PD-L1 interaction with an IC50 value of 0.88 μM by cell-based PD-1/PD-L1 blockade bioassays. LLW-018 has the potential for immunotherapy research[1].
Target Antigen
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/llw-018.html
Smiles
OCC(CO)NCC1=CC=C(NC2=NSC3=C2C=CC=C3C4=C(C)C(COC5=C(Cl)C=C(CNC(CO)CO)C=C5)=CC=C4)C(Cl)=C1
Molecular Weight
697.67
References & Citations
[1]Hanxun Wang, et al. Design, synthesis, pharmacological evaluation, and computational study of benzo[d] isothiazol-based small molecule inhibitors targeting PD-1/PD-l1 interaction. Eur J Med Chem. 2024 Sep 5:275:116622.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161818/LLW-018-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161818/
Clinical Information
No Development Reported
CAS Number
3049369-11-8
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