Garcinol

Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively[1]. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM) . Garcinol has anti-inflammatory and anti-cancer activity[2].

Product Specifications

CAS Number

[78824-30-3]

UNSPSC

12352005

Hazard Statement

H300+H310+H330

Target

Apoptosis; Cholinesterase (ChE) ; Endogenous Metabolite; Histone Acetyltransferase

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/garcinol.html

Concentration

10mM

Purity

99.0

Solubility

DMSO : 50 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic; warming)

Smiles

C/C(C)=C\C[C@@H](C[C@]12C([C@](C(C)([C@@H](C2)C/C=C(C)\C)C)(C/C=C(C)\C)C(C(C(C3=CC(O)=C(C=C3)O)=O)=C1O)=O)=O)C(C)=C

Molecular Formula

C38H50O6

Molecular Weight

602.80

Precautions

H300+H310+H330

References & Citations

[1]Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12 (8) :1548-57.|[2]Ciochina R, et al. Polycyclic polyprenylated acylphloroglucinols. Chem Rev. 2006 Sep;106 (9) :3963-86.|[3]Li F, et al. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signalingcascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila) . 2013 Aug;6 (8) :843-54.