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Garcinol

Product Specifications

UNSPSC Description

Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively[1]. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity[2].

Target Antigen

Apoptosis; Cholinesterase (ChE); Endogenous Metabolite; Histone Acetyltransferase

Type

Natural Products

Related Pathways

Apoptosis;Epigenetics;Metabolic Enzyme/Protease;Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/garcinol.html

Purity

99.0

Solubility

DMSO : 50 mg/mL (ultrasonic)|Ethanol : 20 mg/mL (ultrasonic;warming)

Smiles

C/C(C)=C\C[C@@H](C[C@]12C([C@](C(C)([C@@H](C2)C/C=C(C)\C)C)(C/C=C(C)\C)C(C(C(C3=CC(O)=C(C=C3)O)=O)=C1O)=O)=O)C(C)=C

Molecular Weight

602.80

References & Citations

[1]Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12(8):1548-57.|[2]Ciochina R, et al. Polycyclic polyprenylated acylphloroglucinols. Chem Rev. 2006 Sep;106(9):3963-86.|[3]Li F, et al. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signalingcascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila). 2013 Aug;6(8):843-54.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-107569/Garcinol-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-107569/Garcinol-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

78824-30-3

Available Sizes

Curated Selection

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