Talazoparib
Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity[1].
Product Specifications
CAS Number
[1207456-01-6]
Product Name Alternative
BMN-673; LT-673
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BMN-673.html
Purity
99.89
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1NN=C2C3=C1C=C(F)C=C3N[C@H](C4=CC=C(F)C=C4)[C@H]2C5=NC=NN5C
Molecular Formula
C19H14F2N6O
Molecular Weight
380.35
Precautions
H315, H319, H320
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PARP1; PARP2
Citation 01
Available Sizes
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