SERTlight

SERTlight is a fluorescent agent that can specifically label serotonergic neuronal cell bodies, dendrites, and axonal projections as fluorescent substrates of the serotonin transporter (SERT) . SERTlight is orthogonal to various genetically encoded sensors in terms of optics, pharmacology, and operation, enabling multiple imaging. SERTlight allows the use of GRAB5HT sensors to label distal 5HT axonal projections and simultaneously image the release of endogenous 5HT, providing a new multifunctional molecular tool for studying serotonergic systems[1].

Product Specifications

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sertlight.html

Solubility

10 mM in DMSO

Smiles

OC1=CC(N2)=C(C=C(C2=O)CCN)C=C1F.FC(F)(C(O)=O)F

Molecular Formula

C13H12F4N2O4

Molecular Weight

336.24

References & Citations

[1]Lee WL, et al. Molecular Design of SERTlight: A Fluorescent Serotonin Probe for Neuronal Labeling in the Brain. J Am Chem Soc. 2024;146 (14) :9564-9574.