Pseudocoptisine (chloride)

Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects[1][2].

Product Specifications

CAS Number

[30044-78-1]

Product Name Alternative

Isocoptisine (chloride)

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pseudocoptisine-chloride.html

Purity

99.36

Solubility

DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C12=[N+](C=C3C(C=C4C(OCO4)=C3)=C2)CCC5=CC6=C(OCO6)C=C15.[Cl-]

Molecular Formula

C19H14ClNO4

Molecular Weight

355.77

References & Citations

[1]Hung TM, et al. Anti-amnestic activity of pseudocoptisine from Corydalis Tuber. Biol Pharm Bull. 2008;31 (1) :159-162.|[2]Yun KJ, et al. Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE (2), and pro-inflammatory cytokines production via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells. Int Immunopharmacol. 2009;9 (11) :1323-1331.