NSC 405020
Product Specifications
UNSPSC Description
NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis[1][2][3].
Target Antigen
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/NSC-405020.html
Solubility
DMSO : ≥ 260 mg/mL
Smiles
O=C(NC(C)CCC)C1=CC=C(Cl)C(Cl)=C1
Molecular Weight
260.16
References & Citations
[1]Ren Y, et al. MMP-14 (MT1-MMP) Is a Biomarker of Surgical Outcome and a Potential Mediator of Hearing Loss in Patients With Vestibular Schwannomas. Front Cell Neurosci. 2020 Jul 28;14:191.|[2]Pekkonen P, et al. Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. Elife. 2018 May 1;7:e32490.|[3]Mastenbroek TG, et al. Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity. Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2554-61.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15827/NSC-405020-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15827/NSC-405020-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
7497-07-6
Available Sizes
Curated Selection
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