BTX-6654
BTX-6654 is a target-dependent and -specific cereblon-based bifunctional SOS1 PROTAC degrader. BTX-6654 reduces downstream signaling markers pERK and pS6, and displays antiproliferative activity in cells harboring various KRAS mutations[1].
Product Specifications
UNSPSC
12352005
Target
ERK; PROTACs; SOS1
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btx-6654.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=C(C)C([C@@H](C)NC2=NN=C(C)C3=CC=C(N4CCN(C(C5CCN(C(CCN6CCC(C7=CC(CN(C8CCC(NC8=O)=O)C9=O)=C9C=C7F)CC6)=O)CC5)=O)CC4)C=C32)=CC=C1
Molecular Formula
C50H57F4N9O5
Molecular Weight
940.04
References & Citations
[1]Begovich K, et al. Cereblon-Based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth. Mol Cancer Ther. 2024 Jan 15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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