GSK-J5

GSK-J5 is a potent inhibitor of Schistosome and worm. GSK-J5 increases schistosomula mortality and adult worm motility and mortality, as well as egg oviposition, in a dose- and time-dependent manner[1].

Product Specifications

CAS Number

[1394854-51-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histone Demethylase; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gsk-j5.html

Purity

99.33

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(OCC)CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1

Molecular Formula

C24H27N5O2

Molecular Weight

417.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488 (7411) :404-8.|[2]Horton JR, et al. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. J Biol Chem. 2016 Feb 5;291 (6) :2631-46.|[3]Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514 (7520) :E1-2