MC-VC-PABC-DNA31

MC-VC-PABC-DNA31 is a agent-linker conjugate for ADC with potent antitumor activity by using DNA31 (a potent RNA polymerase inhibitor), linked via the ADC linker MC-VC-PABC.

Product Specifications

CAS Number

[1639352-03-6]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mc-vc-pabc-dna31.html

Purity

98.71

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN1C(C=CC1=O)=O)=O)=O)NC2=CC=C(COC(NC3CCN(C4=CC(OC(C5=N6)=C(NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O7)=O)C(C8=C(O)C(C)=C(O[C@@]7(C)C9=O)C9=C85)=O)=C6C(O)=C4)CC3)=O)C=C2

Molecular Formula

C77H96N10O21

Molecular Weight

1497.64

References & Citations

[1]Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8 (12) :1112-1119.