Apoptosis inducer 32

Apoptosis inducer 32 (Compound 7g) is an apoptosis inducer with a KD of 42 μM, showing anti-tumor activity. Apoptosis inducer 32 caused significant cellular morphological changes in MDA-MB-231 cells, including membrane bubbling, nuclear fragmentation, and apoptotic body formation. The IC50 of Apoptosis inducer 32 in MCF-7, MDA-MB-231, and HEK cells is 4.77, 6.56 and 337.8 μM respectively[1].

Product Specifications

UNSPSC

12352211

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apoptosis-inducer-32.html

Smiles

O=C(NC1=CC=C(Cl)C=C1Cl)NC2=C3C([C@@]([C@@]4([H])OC(C5=C4C=CC(OC)=C5OC)=O)([H])N(C)CC3)=C(OC)C6=C2OCO6

Molecular Formula

C29H27Cl2N3O8

Molecular Weight

616.45

References & Citations

[1]Pratyush Pragyandipta, et al. In silico inspired design of urea noscapine congeners as anticancer agents: Chemical synthesis and experimental evaluation using breast cancer cells and a xenograft mouse model. Eur J Med Chem. 2025 Jan 15:282:117091.